ABSTRACT
Post-translational modifications (PTMs) on histone proteins are known as epigenetic marks that demarcate the status of chromatin. These modifications are 'read' by specific reader proteins, which in turn recruit additional factors to modulate chromatin accessibility and the activity of the underlying DNA. Accumulating evidence suggests that these modifications are not restricted solely to histones, many non-histone proteins may function in a similar way through mimicking the histones. In this commentary, we briefly discuss a systematic study of the discovery of histone H3 N-terminal mimicry proteins (H3TMs), and their implications in chromatin regulation and drug discoveries.
Subject(s)
Chromatin/metabolism , DNA/metabolism , Histones/metabolism , Protein Processing, Post-Translational , Animals , Chromatin/genetics , Chromatin Assembly and Disassembly , DNA/genetics , Humans , Lysine/metabolism , Methylation , Models, BiologicalABSTRACT
The key features of 5G network (i.e., high bandwidth, low latency, and high concurrency) along with the capability of supporting big data platforms with high mobility make it valuable in coping with emerging medical needs, such as COVID-19 and future healthcare challenges. However, enforcing the security aspect of a 5G-based smart healthcare system that hosts critical data and services is becoming more urgent and critical. Passive security mechanisms (e.g., data encryption and isolation) used in legacy medical platforms cannot provide sufficient protection for a healthcare system that is deployed in a distributed manner and fail to meet the need for data/service sharing across "cloud-edge-terminal" in the 5G era. In this article, we propose a security awareness and protection system that leverages zero-trust architecture for a 5G-based smart medical platform. Driven by the four key dimensions of 5G smart healthcare including "subject" (i.e., users, terminals, and applications), "object" (i.e., data, platforms, and services), "behavior," and "environment," our system constructs trustable dynamic access control models and achieves real-time network security situational awareness, continuous identity authentication, analysis of access behavior, and fine-grained access control. The proposed security system is implemented and tested thoroughly at industrial-grade, which proves that it satisfies the needs of active defense and end-to-end security enforcement of data, users, and services involved in a 5G-based smart medical system.